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Patent Granted Interstitial cystitis,[1] or bladder pain syndrome (also IC/BPS), is a chronic inflammatory condition of the submucosal and muscular layers of the bladder.[2] The cause of IC/BPS is currently unknown and the condition is regarded as a diagnosis of exclusion. IC/BPS may be associated with urinary urgency, urinary frequency, waking at night to urinate (nocturia), and sterile urine cultures.