Enhancing vaccine efficacy

Patent Pending Vaccine efficacy is defined as the reduction in the incidence of a disease among people who have received a vaccine compared to the incidence in unvaccinated people. It is usually measured in a randomised controlled trial (RCT) The efficacy of a new vaccine is measured in phase II or phase III clinical trials by giving one group of people a vaccine and comparing the incidence of disease in that group to another group of people who do not receive the vaccine. Ideally the trial is a randomized controlled trial (preferably "double-blind").