Enterotoxins for immunization

Patent Granted Enterotoxins produced by ETEC include heat-labile enterotoxin (LT) and heat-stable enterotoxin (ST).[4] Some strains of ETEC produce a heat-labile exotoxin (LT) that is under the genetic control of a plasmid. The strain also triggers fimbrial adhesion that extends from the surface of the E. coli cell and has a B subunit that attaches to the GM1 ganglioside at the brush border of the small intestine epithelium cell and stimulates the entry of the A subunit into the cell, where the latter activates adenylyl cyclase.[3] This increases the amount of cAMP, and results in intense and prolonged hypersecretion of chlorides and water; while also inhibiting the reabsorption of sodium.