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Patent Granted Thrombolytic agents are used for the treatment of myocardial infarction (heart attack),[2] thromboembolic strokes, deep vein thrombosis and pulmonary embolism to clear a blocked artery and avoid permanent damage to the perfused (see perfusion) tissue (e.g. myocardium, brain, leg) and death.[3] They may also be used to clear blocked catheters that are used in long-term medical therapy. Thrombolytic therapy in hemorrhagic strokes is contraindicated, as its use in that situation would prolong bleeding into the intracranial space and cause further damage.