Inhibiting necroptosis

Patent Granted Necroptosis is a programmed form of necrotic cell death. Necrotic cell death has been considered a form of passive cell death. However, the discovery that TNFalpha mediated necrosis can be inhibited by a specific inhibitor of RIP1 kinase, necrostatin-1, led to the concept of necroptosis;.[1][2][3] Necroptosis has now been established as a regulated necrotic cell death pathway controlled by RIP1 and RIP3 kinases.