Glutamine synthetase inhibitor

Patent Pending Methionine Sulfoximine (MSO): MSO is an inhibitor that binds to the glutamate site. Bound to GS, MSO is phosphorylated by ATP that results in an irreversible, non-covalent inhibition of GS. The S-isomer configuration is more inhibitory.[6] Glutamate entry is blocked into the active site by a stabilization of the flexible loop in the active site by MSO.[7] Phosphinothricin[1](PPT, Glufosinate): Phosphinothricin is an inhibitor that binds to the glutamate site. Glufosinate is used as an herbicide. Glufosinate treated plants die due to a buildup of ammonia and a cessation of photosynthesis.[10] Many synthetic inhibitors are available today.