GLO1

Patent Pending ultiple studies have reported evidence that Glo1 expression is correlated with differences in anxiety-like behavior in mice[23][24] as well as behavior in the tail suspension test, which is sensitive to antidepressant drugs;[25] however, the direction of these effects have not always been consistent, which has raised skepticism.[26] Differences in Glo1 expression in mice appear to be caused by a copy number variant that is common among inbred strains of mice.[27] It has been proposed that the behavioral effects of Glo1 are due to the activity of its principal substrate methylglyoxal at GABAA receptors.[28] A small molecule inhibitor of glyoxalase I has been shown to have anxiolytic properties, thus identifying another possible indication for inhibitors of Glyoxalase I.