Mutant LIGHT

Patent Granted Tumor necrosis factor ligand superfamily member 14 is a protein that in humans is encoded by the TNFSF14 gene.[1][2] TNFSF14 has also been designated as CD258,[citation needed] as well as LIGHT.[3] The protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF14, which is a member of the tumor necrosis factor receptor superfamily, and which is also known as a herpesvirus entry mediator ligand (HVEML). This protein may function as a costimulatory factor for the activation of lymphoid cells and as a deterrent to infection by herpesvirus. This protein has been shown to stimulate the proliferation of T cells, and trigger apoptosis of various tumor cells. This protein is also reported to prevent tumor necrosis factor alpha mediated apoptosis in primary hepatocyte.