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Patent Granted Systemic lupus erythematosus Listeni/sɪˈstɛmɪk ˈluːpəs ˌɛrɪθiːməˈtoʊsəs/, often abbreviated as SLE or lupus, is a systemic autoimmune disease (or autoimmune connective tissue disease) that can affect any part of the body. As occurs in other autoimmune diseases, the immune system attacks the body's cells and tissue, resulting in inflammation and tissue damage.[1] It is both a type II[2] and a type III hypersensitivity reaction in which bound antibody-antigen pairs (immune complexes) precipitate and cause a further immune response.