Tuberous sclerosis pathway

Patent Granted Tuberous sclerosis proteins 1 and 2, also known as TSC1 (hamartin) and TSC2 (tuberin), form a protein-complex. The encoding two genes are TSC1 and TSC2. The complex is known as a tumor suppressor. Mutations in these genes can cause tuberous sclerosis. Depending on the grade of the disease, mental retardation, epilepsy and tumors of the skin, retina, heart, kidney and the central nervous system can be symptoms.