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Patent Pending Methotrexate (INN, AAN, BAN and USAN) Listeni/mɛθɵˈtrɛkseɪt/, abbreviated MTX and formerly known as amethopterin, is an antimetabolite and antifolate drug.[3][4] It is used in treatment of cancer, autoimmune diseases, ectopic pregnancy, and for the induction of medical abortions.[5] It acts by inhibiting the metabolism of folic acid.