Fatty acid synthase

Patent Granted Fatty acid synthase (FAS) is an enzyme that in humans is encoded by the FASN gene.[1][2][3][4] Fatty acid synthase is a multi-enzyme protein that catalyzes fatty acid synthesis. It is not a single enzyme but a whole enzymatic system composed of two identical 272 kDa multifunctional polypeptides, in which substrates are handed from one functional domain to the next.[5][6][7][8] Its main function is to catalyze the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids.