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Patent Granted Bryostatins are a group of macrolide lactones first isolated in the 1960s by George Pettit from extracts of a species of bryozoan, Bugula neritina. The structure of bryostatin 1 was determined in 1982.[1] To date 20 different bryostatins have been isolated.[2] Bryostatins are a potent modulators of protein kinase C. They are currently under investigation as anti-cancer agents and as a memory-enhancing agent.
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