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Huntingtin protein

Patent Pending The function of huntingtin is unclear. It is essential for development, and absence of huntingtin is lethal in mice.[5] The protein has no sequence homology with other proteins and is highly expressed in neurons and testes in humans and rodents.[6] Huntingtin upregulates the expression of Brain Derived Neurotrophic Factor (BDNF) at the transcription level, but the mechanism by which huntingtin regulates gene expression has not been determined.

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