TPH1 inhibitors

Patent Granted Tryptophan hydroxylase 1 (tryptophan 5-monooxygenase), also known as TPH1, is an enzyme which in humans is encoded by the TPH1 gene.[1] TPH1 was first discovered to synthesize serotonin in 1988[2] and was thought that there only was a single TPH gene until 2003, while a second form was found in the mouse (Tph2), rat and human brain (TPH2) and the original Tph/TPH was then renamed to Tph1/TPH1.