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Patent Pending Based on cell growth experiments, animal cancer models, and epidemiological studies, it appears that IGFBP-3 functions as a low-penetrance tumor suppressor gene.[5] Dysregulation of IGFBP-3 has been implicated in many cancers.[35] IGFBP-3 is sometimes referred to as a tumor suppressor, and downregulation of its tissue expression by promoter hypermethylation in some cancers, such as hepatoma.
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