Antisense oligonucleotide delivery

Patent Granted Because nucleases that cleave the phosphodiester linkage in DNA are expressed in almost every cell, unmodified DNA molecules are generally degraded before they reach their targets. Therefore, antisense drug candidate molecules are generally modified during the drug discovery phase of their development.[13][14] Additionally, most targets of antisense are located inside cells, and getting nucleic acids across cell membranes is also difficult.