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Patent Pending The HIV viral protein gp120 induces apoptosis of neuronal cells by inhibiting levels of furin and tissue plasminogen activator, enzymes responsible for converting pBDNF to mBDNF.[17] gp120 induces mitochondrial-death proteins like caspases which may influence the upregulation of the death receptor Fas leading to apoptosis of neuronal cells,[18] gp120 induces oxidative stress in the neuronal cells,[19] and it is also known to activate STAT1 and induce interleukins IL-6 and IL-8 secretion in neuronal cells.
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