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Patent Granted Neuregulin 1 or NRG1 is a protein that in humans is encoded by the NRG1 gene.[1][2] NRG1 is one of four proteins in the neuregulin family that act on the EGFR family of receptors. Neuregulin 1 is produced in numerous isoforms by alternative splicing, which allows it to perform a wide variety of functions. It is essential for the normal development of the nervous system and the heart.