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Patent Pending According to the lipid hypothesis, since cholesterol (like all fat molecules) is transported around the body (in the water outside cells) inside lipoprotein particles, elevated cholesterol concentrations (hypercholesterolemia) — potentially offers a lower cost way to detect elevated concentrations of LDL particles; possibly even low concentrations of functional HDL particles — both variations strongly associated with cardiovascular disease because LDL particles promote atheroma development in arteries (atherosclerosis).