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Patent Pending Proto-oncogene protein Wnt-1 is a protein that in humans is encoded by the WNT1 gene.[1][2] Cardiovascular disease (CVD) is a class of diseases that involve the heart or blood vessels.[1] Common CVDs include: ischemic heart disease (IHD), stroke, hypertensive heart disease, rheumatic heart disease (RHD), aortic aneurysms, cardiomyopathy, atrial fibrillation, congenital heart disease, endocarditis, and peripheral artery disease (PAD), among others.