Actin cytoskeletal rearrangement

Patent Granted The thinnest filaments found in the cytoskeleton are microfilaments. They are composed of linear polymers of G-actin subunits, and generate force when the growing (plus) end of the filament pushes against a barrier, such as the cell membrane. They also act as tracks for the movement of myosin molecules that attach to the microfilament and "walk" along them. Myosin motoring along F-actin filaments generates contractile forces in so-called actomyosin fibers, both in muscle as well as most non-muscle cell types.