Ras superfamily

Patent Granted The Ras superfamily is a protein superfamily of small GTPases, which are all related, to a degree, to the Ras protein subfamily (the key human members of which are KRAS, NRAS, and HRAS). There are more than a hundred proteins in the Ras superfamily.[1] Based on structure, sequence and function, the Ras superfamily is divided into five main families (Ras, Rho, Ran, Rab and Arf GTPases).[2] The Ras family itself is further divided into 6 subfamilies: Ras, Ral, Rit, Rap, Rheb, Rad and Rit. Miro is a recent contributor to the superfamily. Each subfamily shares the common core G domain, which provides essential GTPase and nucleotide exchange activity.