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Patent Granted Dysfunction of dopaminergic neurotransmission in the CNS has been implicated in a variety of neuropsychiatric disorders, including social phobia,[17] Tourette's syndrome,[18] Parkinson's disease,[19] schizophrenia,[18] neuroleptic malignant syndrome,[20] attention-deficit hyperactivity disorder (ADHD),[21] and drug and alcohol dependence.