Apaf-1 protein

Patent Granted Apoptotic protease activating factor 1, also known as APAF1, is a human homolog of C. elegans CED-4 gene.[2][3][4] APAF-1 and CED-4 homologs have been found in all currently sequenced animal genomes. This gene encodes a cytoplasmic protein that forms one of the central hubs in the apoptosis regulatory network. This protein contains (from the N terminal) a caspase recruitment domain (CARD), an ATPase domain (NB-ARC), few short helical domains and then several copies of the WD40 repeat domain. Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome.