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Patent Pending The pathogenesis of a disease is the biological mechanism (or mechanisms) that lead to the diseased state. The term can also describe the origin and development of the disease, and whether it is acute, chronic, or recurrent. The word comes from the Greek pathos ("disease") and genesis ("creation"). Types of pathogenesis include microbial infection, inflammation, malignancy and tissue breakdown. For example bacterial pathogenesis is the mechanism by which bacteria cause infectious illness.