Oncolytic vesicular stomatitis virus

Patent Granted In healthy human cells the virus cannot reproduce, probably because of the interferon response.[further explanation needed] Many cancer cells have a reduced interferon response, which probably allows VSIV to grow and hence lyse the oncogenic cells preferentially.[7] Recently, attenuated VSIV with a mutation in its M protein has been found to have oncolytic properties. Research is ongoing, and has shown VSIV to reduce tumor size and spread in melanoma, lung cancer, colon cancer and certain brain tumors in laboratory models of cancer.