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Patent Granted Interleukin 11 (IL-11) is a protein that in humans is encoded by the IL11 gene.[1] IL-11 is a multifunctional cytokine first isolated in 1990 from bone marrow-derived stromal cells. It is a key regulator of multiple events in hematopoiesis, most notably the stimulation of megakaryocyte maturation.[2] It is also known under the names adipogenesis inhibitory factor (AGIF)[3] and oprelvekin.