Deoxycytidine kinase inhibtors

Patent Pending Deoxycytidine kinase, also known as DCK, is an enzyme which in humans is encoded by the DCK gene.[1] DCK transfers phosphate to deoxycytidine. Deoxycytidine kinase (DCK) is required for the phosphorylation of several deoxyribonucleosides and their nucleoside analogs. Deficiency of DCK is associated with resistance to antiviral and anticancer chemotherapeutic agents. Conversely, increased deoxycytidine kinase activity is associated with increased activation of these compounds to cytotoxic nucleoside triphosphate derivatives. DCK is clinically important because of its relationship to drug resistance and sensitivity.