Hemoglobin

Patent Granted One other form of HBOCs is encapsulated haemoglobin, where the haemoglobin is packed inside an artificial neohemocyte ("new blood cell"). In the 1950s, the first form of encapsulated haemoglobin was developed but limited technical possibility and absence of public interest slowed further development until the HIV crisis . Liposome-encapsulated haemoglobin (LEH) has been found to be an effective oxygen carrier, without the adverse effects of vasoconstriction.[8] The liposome encapsulation appears to increase plasma retention time; however, adverse immune interactions occur with the liposome.