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Patent Granted Cholera is an infection of the small intestine by some strains of the bacterium Vibrio cholerae.[1] Symptoms may range from none, to mild, to severe.[2] The classic symptom is large amounts of watery diarrhea that lasts a few days.[3] Vomiting and muscle cramps may also occur.[2] Diarrhea can be so severe that it leads within hours to severe dehydration and electrolyte imbalance.