Aquaporin modulators

Patent Granted If aquaporin could be manipulated, that could potentially solve medical problems such as fluid retention in heart disease and brain edema after stroke.[7] There have been two clear examples of diseases identified as resulting from mutations in aquaporins: Mutations in the aquaporin-2 gene cause hereditary nephrogenic diabetes insipidus in humans.[33] Mice homozygous for inactivating mutations in the aquaporin-0 gene develop congenital cataracts.